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  • Guide to Cannabinoids: The Differences Between THC, CBD, CBG, CBN and CBC and Their Different Uses

    Guide to Cannabinoids: The Differences Between THC, CBD, CBG, CBN and CBC and Their Different Uses

    What Are Cannabinoids? 

    Cannabinoids are chemical compounds that work in conjunction with your body’s endocannabinoid system. The endocannabinoid system regulates and balances many functions in the body, including immunity, communication between cells, appetite, metabolism, and memory.  

    Cannabinoids can be classified into three groups:  

    1. Endocannabinoids (produced within the body) 
    2. Phytocannabinoids (naturally occurring in the cannabis plant) 
    3. Synthetic cannabinoids (built in the laboratory) 

    Over 100 phytocannabinoids have been identified in the cannabis plant1. These phytocannabinoids are found in concentrated amounts in the flowers of the cannabis plant.  

    Each compound is thought to have unique properties, meaning that each of them has different medical benefits. 

    What Are the Different Classes of Cannabinoids? 

    Phytocannabinoids belong to two classes: major and minor phytocannabinoids.  

    Major phytocannabinoids include ∆9-tetrahydrocannabinol (THC) and cannabidiol (CBD). THC and CBD are thought to be responsible for the majority of the physiological effects induced by cannabis2. 

    Minor cannabinoids appear in smaller quantities in the plant. Common minor cannabinoids include:  

      •  Tetrahydrocannabivarin (THCV) 
      •  Cannabinol (CBN) 
      •  Cannabigerol (CBG) 
      •  Cannabichromene (CBC) 
      •  Cannabidiolic acid (CBDA) 
      •  Cannabidivarin (CBDV)3  

    The effect of phytocannabinoids depends on their interactions with receptors in our body.   

    What Is the Cannabinoid Receptor System? 

    Endocannabinoids are part of the physiological system called the endocannabinoid system (ECS). They interact with many different protein targets throughout the body to induce their effects5,6.    

    The endocannabinoid system consists of endogenous cannabinoids (naturally occurring cannabinoid molecules made in the body) and their receptors. 

    There are two main cannabinoid receptors:  

      •  Cannabinoid receptor 1 (CB1R), which is found on neurons in the central nervous system (i.e., brain) and in low concentrations in peripheral organs (i.e., heart, liver, fat tissue, stomach)7
      •  Cannabinoid receptor 2 (CB2R), which is mostly found in the immune system, microglia, and gastrointestinal system7 

    There are two major endocannabinoids that bind to the cannabinoid receptors. Some examples of functions the endocannabinoid system regulates include:  

      •  Learning and memory processes 
      •  Sleep
      •  Stress
      •  Emotions   
      •  Pain 
      •  Immune responses6 

    Phytocannabinoids (THC and CBD) and synthetic cannabinoids (Dronabinol and Nabilone) interact with many of the same protein targets that endocannabinoids do, resulting in an overlap of activities. 

    What Are Cannabinoid Acids? 

    In the cannabis plant, phytocannabinoids like THC and CBD are not produced in large amounts directly by the plant.  

    Instead, they exist mostly in their acidic forms. They are called tetrahydrocannabinolic acid (THCA) and cannabidiolic acid (CBDA) and exist in smaller amounts in their decarboxylated forms (i.e., THC, CBD)4 

    These cannabinoid acids (i.e., THCA, CBDA) turn into their decarboxylated forms (i.e., THC, CBD) through the process called decarboxylation. 

    Decarboxylation is the process that activates compounds in cannabis such as THC1,4.  This happens when certain cannabinoid acids are exposed to heat such as sunlight or in an oven.  

    Main Differences Between Major Cannabinoids 

    Besides being the most popular among users, THC and CBD are the two most abundant phytocannabinoids. 

    They have a couple of key differences between them, including their molecular structure and how they affect the body.  

    What is THC? 

    THC is the primary intoxicating molecule in cannabis and allows the user feel the euphoria associated with being “high.” In addition, THC has the potential to relieve pain, inflammation and nausea/vomiting2. 

    What is CBD? 

    CBD’s popularity has rapidly grown in medical cannabis applications due to its unique therapeutic profile and effects.  

    CBD is non-intoxicating at therapeutically relevant doses and may reduce pain, anxiety and inflammation2. It has also been shown to be an effective anti-epileptic8. 

    What is CBG? 

    CBG is the third most prevalent cannabinoid after THC and CBD. This cannabinoid is produced early in the cannabis plant’s growth cycle. It is a predecessor from which other cannabinoids are then synthesized.   

    Emerging evidence from pre-clinical studies shows that CBG has many potential medical benefits, such as: 

      •  Anti-inflammatory and analgesic properties23–27 
      •  Anti-bacterial properties28,29 
      •  Antiproliferative effects30–32 
      •  Inflammatory bowel disease regulation30,33 
      •  Appetite regulation34  

    What is CBN? 

    Cannabinol (CBN) is a product of THC.  

    CBN concentrations and extracts are low in plant material but increase overtime as THC is exposed to light, oxygen, and heat. It is also less potent than THC. 

    Clinical studies have shown that the chemistry, pharmacology, therapeutic effects, and adverse effects of CBN are well-suited for medical cannabis patients10–14. 

    A few clinical studies have shown that the combination of THC and CBN improved various aspects of sleep quality12,15,16. 

    What is THCV?  

    THCV is structurally similar to THC17 

    Clinical studies have shown that the chemistry, pharmacology, therapeutic effects, and adverse effects of CBN are well-suited for medical cannabis patients18–22 

    Studies shown that THCV has the potential to treat obesity18,19 and diabetes/metabolic syndrome21. 

    What is Cannabichromene (CBC)? 

    CBC is rare and produced early in the plant’s flowering cycle. It is both antibiotic and antifungal, as these two properties may protect the plant in its early life35. Emerging evidence from pre-clinical studies has shown that CBC may have potential medical benefits such as:  

      •  Anti-inflammatory and analgesic effects36–39
      •  Anti-acne properties40 
      •  
    Antidepressant effects41 
      •  
    Anti-inflammatory activity
      •  
    Strong anti-bacterial activity
      •  
    Mild to moderate anti-fungal activity42
      •  
    Low toxicity42 

    Other cannabinoids 

    There are hundreds of other minor cannabinoids that are present in the cannabis plant. Some of the other more popular minor cannabinoids include:   

      •  Δ8-THC (Delta-8-THC) 
      •  
    Δ9-THC (Delta-9-THC) 
      •  
    CBDP
      •  
    THC-O
      •  
    CBD-V
      •  
    CBC-V 

    How Do I Know Which Cannabinoid Works Best? 

    When choosing a product, you want to think about what symptom or condition you are looking to treat and what dosage your healthcare practitioner has suggested.  

    Once you have the recommended dose you can find the products that are best suited for you.  

    For instance, if your healthcare practitioner recommended you a higher THC dose then you would likely want to find a product with higher THC potency. That way, you don’t have to consume significantly large amounts to get the desired dose. However, if you were recommended a lower dose of THC, a low to medium THC product may be best.  

    It is also good to consider if any compounds other than THC and CBD may be helpful for your treatment. The compounds in cannabis are thought to work together to influence the overall effect you feel when you consume cannabis.  

    This is called the Entourage Effect and is a hypothesis that cannabinoids are more effective when combined than on their own.  For example, some studies suggest that CBD extracts may be more effective than CBD alone at reducing pain and inflammation43,44 

    How Do I Consume Medical Cannabis? 

    Patients have several options when it comes to the consumption of their medical cannabis.  Common formats include inhalation, ingestion, and sublingual/oromucosal. Let us break them down for you:  

    Inhalation (i.e., smoking, vaporizing): 

      •  When smoking or vaping medical cannabis, the absorption of cannabis occurs through the lungs.  

      •  This allows for quicker onset, with effects felt within seconds to minutes of dosing and peak within 30 minutes46,47. However, it also results in a shorter duration of effect, lasting up to 6 hours47. Because the effects are felt almost instantaneously, this route of administration may help those experiencing acute symptoms like breakthrough pain.   

      •  What’s the advantage? Inhalation is the more efficient delivery of cannabinoids46.   

    Ingestion (i.e., oils, capsules, edibles): 

      •  When you ingest medical cannabis, the absorption of cannabis occurs through the gastrointestinal tract.  

      •  There is a slower onset of action (effects felt within 0.5-4 hours) and lower peak blood levels of cannabinoids47,48 However, the duration of the effects is much longer (may last up to 12 hours or longer47,48) compared to inhalation. 

      •  What’s the advantage? Ingestion is useful for chronic conditions that require higher dosage and longer half-life.  

    Oromucosal/sublingual (i.e., sprays, oils): 

      •  When sprays or oils are held inside the mouth, absorption occurs through the cheek or under the tongue.  

      •  This allows for the onset and duration of the effects to be quicker and shorter than oral ingestion but slower and longer than inhalation49. 

      •  What’s the advantage? Oromucosal/sublingual methods have faster onset and shorter duration than oral ingestion.   

    What Are Some Products to Consider?  

    THC Products 

    Stellio Oil (Indica) 

    Carefully extracted from indica-dominant and THC-rich Stellio strain, Stellio Oil offers a rich combination of cannabinoids and terpenes. This oil is created using an advanced CO2 extraction process and contains a high dose of THC (20 mg/ml) held in a non-GMO high-oleic sunflower carrier oil. 

    To get started, simply measure out your desired dose using included syringe, and then release under the tongue to experience its effects.  

    Sedamen Oil (Indica) 

    Sedamen® Oil has a rich and potent combination of cannabinoids extracted from the THC-rich Sedamen indica strain. Created through our state-of-the-art CO2 extraction process, this oil delivers high doses of THC (20 mg/ml) in non-GMO sunflower carrier oils.  

    To get started, simply measure out the desired dose using an included syringe for higher accuracy, and then release it under your tongue.  

    Ambition (Sativa) 

    If your preferred method of consuming medical cannabis is through smoking or vaporizing, Ambition might be the right fit for you. 

    Also known as Blue Dream, this high-THC (20 – 23%) sativa strain offers a fresh and uplifting experience. Flavour notes include pine, pepper, and lemon.  

    Ambition grows at Aurora’s state-of-the-art facilities with top quality standards, and is ready to be used in a dried cannabis vaporizer. Just remember that if you are new to this strain, it is better to start off slowly with a low dose.  

    CBD Products 

    Peach CBD Gummies (Hybrid)  

    Aurora’s Peach CBD Gummies are a delicious way to consume your CBD treatment. These five gummies are perfectly infused with high quality distillate of our most popular CBD strains for guaranteed consistency. Each of them contains 10mg of CBD. 

    To get started simply remove the gummy from its packaging, put it in your mouth and chew before swallowing. If you’re trying these gummies for the first time, start with one unless otherwise recommended by your healthcare practitioner. 

    Trutiva (Sativa) 

    Trutivia is a high-CBD (15.6 - 20%) sativa strain with a bright, floral aroma. This strain doesn’t produce the “high” or euphoric feeling often associated with cannabis at therapeutically relevant doses, making it an ideal product for people looking to start their journey into medical cannabis and those who want to add CBD into their treatment regimen alike. 

    Even though it might not cause a euphoric feeling, if you haven’t used Trutiva before you should start off slowly as you get accustomed to its effects. 

    Vespera Oil (Indica) 

    Vespera Oil is extracted from our high-CBD indica-dominant Vespera strain. Our proprietary CO2 extraction method preserves the original plant cannabinoids, resulting in a full-spectrum resin that is mixed with a non-GMO high-oleic sunflower carrier oil.

    This high quality CBD product has 26 mg/g of CBD and <3.3 mg/g of THC. To get started, simply measure out the desired dose using an included syringe for higher accuracy, and then release it under your tongue.  

    Ginger-Lemon CBD Oral Spray (Hybrid) 

    Ginger-Lemon CBD Oral Spray is a high-CBD (25 mg/g) spray with an invigorating, tangy feeling in each spritz. Aurora's award winning* product line has just been extended to include this refreshing new flavor! Four simple ingredients make up this product: MCT oil, ginger and lemon oils, and CBD-rich cannabis extract. 

    There is no preparation required; just spray Ginger-Lemon CBD Oral Spray into your mouth, pointing the nozzle into your cheek or under your tongue. 

    *Our Sativa Oral Spray was a 2019 Canadian Cannabis Awards Winner – Top Cannabis Spray  

    CBD vs THC Oil 

    Aurora CBD Drops (Hybrid) 

    Aurora CBD Drops offer a rich combination of CBD and terpenes extracted from Aurora’s extremely popular high-CBD strain, Tower, using Aurora's CO2 extraction process. 

    This high-CBD (26 mg/ml), low-THC cannabis extract also preserves Tower’s unique blend of terpenes, which are held in a medium-chain triglyceride (MCT) carrier oil.  

    To get started with these drops, you can simply place the dose you want under your tongue 

    .Aurora THC Drops (Sativa) 

    Similarly to Aurora CBD Drops, Aurora THC Drops are created using Aurora’s CO2 extraction process, but are extracted from Aurora’s most popular sativa strains. 

    These drops deliver THC-rich (20 mg/ml) extract in a medium-chain triglyceride (MCT) carrier oil. As you place the dose you want under your tongue, we recommend that you start off with a low dose and wait a minimum of 120 minutes before consuming another. 

    CBG Products 

    Organic High CBG Oil (Indica) 

     This cannabis oil is derived from an indica-dominant hybrid CBG Shiatsu, which has a woodsy, sweet pine scent.  

    As a result, this oil is rich is CBG (6.1 mg/ml) and low in THC, and has a terpene profile of caryophyllene, borneol isomers, and d-limonene.  

    Final Notes on the Cannabinoids Differences and Effects 

    Each of the cannabinoids mentioned offers its own unique set of medical benefits. Finding a cannabis product that is right for you is a highly individualized process that requires medical oversight.  

    This is especially important if you take multiple pharmaceuticals due to drug-drug interactions or have multiple medical conditions. You should always consult a healthcare practitioner as effects may vary on an individual basis. 

    If you’re new to medical cannabis, Aurora’s clinic partner, Canadian Cannabis Clinics, offers free virtual appointments and will assist you in getting started on your medical cannabis journey. You can book an appointment here. 

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    References 

    1. Information for Health Care Professionals Cannabis (marihuana, marijuana) and the cannabinoids.
    2. Baron EP. Medicinal Properties of Cannabinoids, Terpenes, and Flavonoids in Cannabis, and Benefits in Migraine, Headache, and Pain: An Update on Current Evidence and Cannabis Science. Headache: The Journal of Head and Face Pain. 2018;58(7):1139-1186. doi:10.1111/head.13345
    3. Marcu JP. An Overview of Major and Minor Phytocannabinoids. Neuropathology of Drug Addictions and Substance Misuse. 2016;1:672-678. doi:10.1016/B978-0-12-800213-1.00062-6
    4. Perrotin-Brunel H, Buijs W, Spronsen J van, et al. Decarboxylation of Δ9-tetrahydrocannabinol: Kinetics and molecular modeling. Journal of Molecular Structure. 2011;1-3(987):67-73. doi:10.1016/J.MOLSTRUC.2010.11.061
    5. de Petrocellis L, di Marzo V. An introduction to the endocannabinoid system: from the early to the latest concepts. Best Practice & Research Clinical Endocrinology & Metabolism. 2009;23(1):1-15. doi:10.1016/j.beem.2008.10.013
    6. Aizpurua-Olaizola O, Elezgarai I, Rico-Barrio I, Zarandona I, Etxebarria N, Usobiaga A. Targeting the endocannabinoid system: future therapeutic strategies. Drug Discovery Today. 2017;22(1):105-110. doi:10.1016/j.drudis.2016.08.005
    7. Iversen L. Cannabis and the brain. Brain. 2003;126(6):1252-1270. doi:10.1093/brain/awg143
    8. Lattanzi S, Brigo F, Trinka E, et al. Efficacy and Safety of Cannabidiol in Epilepsy: A Systematic Review and Meta-Analysis. Drugs. 2018;78(17):1791-1804. doi:10.1007/s40265-018-0992-5
    9. National Academies of Sciences E and M, Division H and M, Practice B on PH and PH, Agenda C on the HE of MAER and R. Therapeutic Effects of Cannabis and Cannabinoids. Published online January 12, 2017. Accessed June 27, 2021. https://www.ncbi.nlm.nih.gov/books/NBK425767/
    10. Perez-Reyes M, Timmons MC, Davis KH, Wall EM. A comparison of the pharmacological activity in man of intravenously administered 1368-11368-11368-1, cannabinol, and cannabidiol. Experientia. 1973;29(11):1368-1369. doi:10.1007/BF01922823
    11. Hollister LE. Cannabidiol and cannabinol in man. Experientia 1973 29:7. 1973;29(7):825-826. doi:10.1007/BF01946311
    12. Karniol IG, Shirakawa I, Takahashi RN, Knobel E, Musty RE. Effects of Δ9-tetrahydrocannabinol and cannabinol in man. Pharmacology. 1975;13(6):502-512. doi:10.1159/000136944
    13. Hollister LE, Gillespie H. Interactions in man of delta-9-tetrahydrocannabinol; II. Cannabinol and cannabidiol. Clinical Pharmacology & Therapeutics. 1975;18(1):80-83. doi:10.1002/CPT197518180
    14. Agurell S, Carlsson S, Lindgren JE, Ohlsson A, Gillespie H, Hollister L. Interactions ofΔ 11-tetrahydrocannabinol with cannabinol and cannabidiol following oral administration in man. Assay of cannabinol and cannabidiol by mass fragmentographywith cannabinol and cannabidiol following oral administration in man. Assay of cannabinol and cannabidiol by mass fragmentography. Experientia 1981 37:10. 1981;37(10):1090-1092. doi:10.1007/BF02085029
    15. Walsh JH, Maddison KJ, Rankin T, et al. Treating Insomnia Symptoms with Medicinal Cannabis: A Randomized, Cross-Over Trial of the Efficacy of a Cannabinoid Medicine Compared with Placebo. Sleep. Published online June 11, 2021. doi:10.1093/SLEEP/ZSAB149
    16. Gannon WE, Bronfein W, Jackson DS, et al. Novel Formulation of THC and CBN in a Repeat-Action Tablet Improves Objective and Subjective Measurements of Sleep. American Journal of Endocannabinoid Medicine I. 3(1). Accessed July 12, 2021. www.ajendomed.com
    17. Nazarenus C. Cannabinoids and Terpenes. In: Medical Cannabis Handbook. Springer Publishing Company; 2019. doi:10.1891/9780826135735.0005
    18. Tudge L, Williams C, Cowen PJ, McCabe C, Williams K, in Neuroscience L. Neural Effects of Cannabinoid CB1 Neutral Antagonist Tetrahydrocannabivarin on Food Reward and Aversion in Healthy Volunteers. International Journal of Neuropsychopharmacology. Published online 2015:1-9. doi:10.1093/ijnp/pyu094
    19. Rzepa E, Tudge L, McCabe C. The CB1 Neutral Antagonist Tetrahydrocannabivarin Reduces Default Mode Network and Increases Executive Control Network Resting State Functional Connectivity in Healthy Volunteers. International Journal of Neuropsychopharmacology. 2016;19(2):1-7. doi:10.1093/IJNP/PYV092
    20. Hollister LE. Structure-Activity Relationships in Man of Cannabis Constituents, and Homologs and Metabolites of Δ9-Tetrahydrocannabinol. Pharmacology. 1974;11(1):3-11. doi:10.1159/000136462
    21. Jadoon KA, Ratcliffe SH, Barrett DA, et al. Efficacy and safety of cannabidiol and tetrahydrocannabivarin on glycemic and lipid parameters in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled, parallel group pilot study. Diabetes Care. 2016;39(10):1777-1786. doi:10.2337/dc16-0650
    22. Englund A, Atakan Z, Kralj A, Tunstall N, Murray R, Morrison P. The effect of five day dosing with THCV on THC-induced cognitive, psychological and physiological effects in healthy male human volunteers: A placebo-controlled, double-blind, crossover pilot trial. Journal of Psychopharmacology. 2016;30(2):140-151. doi:10.1177/0269881115615104
    23. Barrett ML, Gordon D, Evans FJ. Isolation from cannabis sativa L. of cannflavin-a novel inhibitor of prostaglandin production. Biochemical Pharmacology. 1985;34(11):2019-2024. doi:10.1016/0006-2952(85)90325-9
    24. Evans AT, Formukong E, Evans FJ. Activation of phospholipase A2 by cannabinoids. Lack of correlation with CNS effects. FEBS Letters. 1987;211(2):119-122. doi:10.1016/0014-5793(87)81420-5
    25. Ruhaak LR, Felth J, Karlsson PC, Rafter JJ, Verpoorte R, Bohlin L. Evaluation of the cyclooxygenase inhibiting effects of six major cannabinoids isolated from Cannabis sativa. Biological and Pharmaceutical Bulletin. 2011;34(5):774-778. doi:10.1248/bpb.34.774
    26. de Petrocellis L, Ligresti A, Moriello AS, et al. Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes. British Journal of Pharmacology. 2011;163(7):1479-1494. doi:10.1111/j.1476-5381.2010.01166.x
    27. Formukong EA, Evans AT, Evans FJ. Analgesic and antiinflammatory activity of constituents of Cannabis sativa L. Inflammation. 1988;12(4):361-371. doi:10.1007/BF00915771
    28. Mechoulam R, Gaoni Y. A Total Synthesis of dl-Δ1-Tetrahydrocannabinol, the Active Constituent of Hashish1. Journal of the American Chemical Society. 2002;87(14):3273-3275. doi:10.1021/JA01092A065
    29. Eisohly HN, Turner CE, Clark AM, Eisohly MA. Synthesis and antimicrobial activities of certain cannabichromene and cannabigerol related compounds. Journal of Pharmaceutical Sciences. 1982;71(12):1319-1323. Accessed July 4, 2021. https://onlinelibrary.wiley.com/doi/full/10.1002/jps.2600711204
    30. Guzmán M. Cannabinoids: Potential anticancer agents. Nature Reviews Cancer. 2003;3(10):745-755. doi:10.1038/nrc1188
    31. Lah TT, Novak M, Pena Almidon MA, et al. Cannabigerol Is a Potential Therapeutic Agent in a Novel Combined Therapy for Glioblastoma. Cells. 2021;10(2). doi:10.3390/cells10020340
    32. Baek SH, du Han S, Yook CN, Kim YC, Kwak JS. Synthesis and antitumor activity of cannabigerol. Archives of Pharmacal Research 1996 19:3. 1996;19(3):228-230. doi:10.1007/BF02976895
    33. Borrelli F, Fasolino I, Romano B, et al. Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease. Biochemical Pharmacology. 2013;85(9):1306-1316. doi:10.1016/j.bcp.2013.01.017
    34. Brierley DI, Samuels J, Duncan M, Whalley BJ, Williams CM. Cannabigerol is a novel, well-tolerated appetite stimulant in pre-satiated rats. Psychopharmacology. 2016;233(19):3603. doi:10.1007/S00213-016-4397-4
    35. Turner CE, Elsohly MA. Biological activity of cannabichromene, its homologs and isomers. Journal of clinical pharmacology. 1981;21(8-9 Suppl). doi:10.1002/j.1552-4604.1981.tb02606.x
    36. Izzo AA, Capasso R, Aviello G, et al. Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice. British Journal of Pharmacology. 2012;166(4):1444. doi:10.1111/J.1476-5381.2012.01879.X
    37. Cascio RGPMG. Known Pharmacological Actions of Delta-9-Tetrahydrocannabinol and of Four Other Chemical Constituents of Cannabis that Activate Cannabinoid Receptors. Handbook of Cannabis. Published online January 22, 6354:115-136. doi:10.1093/ACPROF:OSO/9780199662685.003.0006
    38. DeLong GT, Wolf CE, Poklis A, Lichtman AH. Pharmacological evaluation of the natural constituent of Cannabis sativa, cannabichromene and its modulation by Δ9-tetrahydrocannabinol. Drug and Alcohol Dependence. 2010;112(1-2):126-133. doi:10.1016/j.drugalcdep.2010.05.019
    39. Iizzo AA, Capasso R, Aviello G, Borrelli F, Romano B, Piscitelli F, Gallo L, Capasso F, Orlando P, Marzo V di (2012) Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice. British Journal of Pharmacology 166:1444.
    40. Oláh A, Markovics A, Szabó-Papp J, Szabó PT, Stott C, Zouboulis CC, Bíró T (2016) Differential effectiveness of selected non-psychotropic phytocannabinoids on human sebocyte functions implicates their introduction in dry/seborrhoeic skin and acne treatment. Experimental Dermatology 25:701–707.
    41. El-Alfy AT, Ivey K, Robinson K, Ahmed S, Radwan M, Slade D, Khan I, ElSohly M, Ross S (2010) Antidepressant-like effect of Δ9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L. Pharmacology Biochemistry and Behavior 95:434–442.
    42. Turner, C. E., & Eilsohly M. A. (1981). Biological activity of cannabichromene, its homologs and isomers. The Journal of Clinical Pharmacology, 21(S1), 283S-291S.
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